Diabetes can lead to neuropathy and below the knee amputation. The path to this result goes through PAD – Peripheral Artery Disease. Sadly, many people with diabetes or peripheral neuropathy don’t know about PAD and can often miss or confuse the related signs and symptoms such as numbness or weakness in legs, sores on toes, feet or legs that don’t heal. Discoloration in legs. Painful cramping in legs after walking on an incline or climbing stairs.